Event-based modeling in temporal lobe epilepsy demonstrates progressive atrophy from cross-sectional data

SM Lopez; LM Aksman; NP Oxtoby; SB Vos; J Rao; E Kaestner; S Alhusaini; M Alvim; B Bender; A Bernasconi; N Bernasconi; B Bernhardt; L Bonilha; L Caciagli; B Caldairou; ME Caligiuri; A Calvet; F Cendes; L Concha; E Conde-Blanco; E Davoodi-Bojd; C de Bézenac; N Delanty; PM Desmond; O Devinsky; M Domin; JS Duncan; NK Focke; S Foley; F Fortunato; M Galovic; A Gambardella; E Gleichgerrcht; R Guerrini; K Hamandi; V Ives-Deliperi; GD Jackson; N Jahanshad; SS Keller; P Kochunov; R Kotikalapudi; BAK Kreilkamp; A Labate; S Larivière; M Lenge; E Lui; C Malpas; P Martin; M Mascalchi; SE Medland; S Meletti; ME Morita-Sherman; TW Owen; M Richardson; A Riva; T Rüber; B Sinclair; H Soltanian-Zadeh; DJ Stein; P Striano; P Taylor; SI Thomopoulos; PM Thompson; M Tondelli; AE Vaudano; L Vivash; Y Wang; B Weber; CD Whelan; R Wiest; GP Winston; CL Yasuda; CR McDonald; D Alexander; SM Sisodiya; A Altmann; N Bargalló; E Bartolini; TJ O’Brien; RH Thomas

Journal article

Event-based modeling in temporal lobe epilepsy demonstrates progressive atrophy from cross-sectional data

SM Lopez, LM Aksman, NP Oxtoby, SB Vos, J Rao, E Kaestner, S Alhusaini, M Alvim, B Bender, A Bernasconi, N Bernasconi, B Bernhardt, L Bonilha, L Caciagli, B Caldairou, ME Caligiuri, A Calvet, F Cendes, L Concha, E Conde-Blanco Show all

Epilepsia | Published : 2022

DOI: 10.1111/epi.17316

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Abstract

Objective: Recent work has shown that people with common epilepsies have characteristic patterns of cortical thinning, and that these changes may be progressive over time. Leveraging a large multicenter cross-sectional cohort, we investigated whether regional morphometric changes occur in a sequential manner, and whether these changes in people with mesial temporal lobe epilepsy and hippocampal sclerosis (MTLE-HS) correlate with clinical features. Methods: We extracted regional measures of cortical thickness, surface area, and subcortical brain volumes from T1-weighted (T1W) magnetic resonance imaging (MRI) scans collected by the ENIGMA-Epilepsy consortium, comprising 804 people with MTLE-HS..

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University of Melbourne Researchers

Patricia Desmond Author

Graeme Jackson Author

Elaine Lui Author

Charles Malpas Author

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Funding Acknowledgements

Engineering and Physical Sciences Research Council, Grant/Award Number: EP/L015358/1 and EP/R513143/1; Medical Research Council, Grant/Award Number: G0802012, MR/K013998/1, MR/K023152/1, MR/L016311/1, MR/M00841X/1, MR/N026063/1, MR/S00355X/1, MR/S03546X/1 and MR/T04294X/1